SwissProt blast output of UN86144
BLASTX 7.6.2
Query= UN86144 /QuerySize=3699
(3698 letters)
Database: Uniprot/SwissProt;
537,505 sequences; 190,795,139 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q304B9|NCASE_ARATH Neutral ceramidase OS=Arabidopsis thaliana... 1076 1e-313
sp|Q0JL46|NCASE_ORYSJ Neutral ceramidase OS=Oryza sativa subsp. ... 1067 1e-310
sp|Q55G11|NCSEB_DICDI Neutral ceramidase B OS=Dictyostelium disc... 374 3e-102
sp|Q54BK2|NCSEA_DICDI Neutral ceramidase A OS=Dictyostelium disc... 350 7e-095
sp|Q29C43|NCASE_DROPS Neutral ceramidase OS=Drosophila pseudoobs... 306 9e-082
sp|Q9VA70|NCASE_DROME Neutral ceramidase OS=Drosophila melanogas... 243 9e-063
sp|Q5W7F1|ASAH2_DANRE Neutral ceramidase OS=Danio rerio GN=asah2... 236 1e-060
sp|Q9NR71|ASAH2_HUMAN Neutral ceramidase OS=Homo sapiens GN=ASAH... 231 3e-059
sp|Q91XT9|ASAH2_RAT Neutral ceramidase OS=Rattus norvegicus GN=A... 231 4e-059
sp|Q9JHE3|ASAH2_MOUSE Neutral ceramidase OS=Mus musculus GN=Asah... 229 2e-058
sp|Q9I596|NCASE_PSEAE Neutral ceramidase OS=Pseudomonas aerugino... 191 4e-047
sp|P0C7U2|ASA2C_HUMAN Putative neutral ceramidase C OS=Homo sapi... 163 9e-039
>sp|Q304B9|NCASE_ARATH Neutral ceramidase OS=Arabidopsis thaliana GN=At2g38010
PE=2 SV=1
Length = 757
Score = 1076 bits (2782), Expect = 1e-313
Identities = 525/735 (71%), Positives = 597/735 (81%), Gaps = 13/735 (1%)
Frame = -2
Query: 2311 YLVGLGSYDITGPAADVNMMGYANSDQTASGIHFRLRSRAFIVAEPQGNRVVFVNLDACM 2132
YL+G+GSYDITGPAADVNMMGYANSDQ ASGIHFRLR+RAFIVAEPQGNRVVFVNLDACM
Sbjct: 26 YLIGVGSYDITGPAADVNMMGYANSDQIASGIHFRLRARAFIVAEPQGNRVVFVNLDACM 85
Query: 2131 GSQLVTLKVLERLKARYGNLYTEKNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQSFDA 1952
SQ+VT+KVLERLKARYG LYTEKNVAISGIHTHAGPGGYLQYV YIVTSLGFVRQSFD
Sbjct: 86 ASQIVTIKVLERLKARYGELYTEKNVAISGIHTHAGPGGYLQYVTYIVTSLGFVRQSFDV 145
Query: 1951 LVDGIEQSIILAHDNLHSGSVYVNKGEILDAGVNRSPSAYLNNPSAERAKYKYDVDKEMT 1772
+V+GIEQSI+ AH++L GS +VNKG++LDAGVNRSPS+YLNNP+AER+KYKYDVDKEMT
Sbjct: 146 VVNGIEQSIVQAHESLRPGSAFVNKGDLLDAGVNRSPSSYLNNPAAERSKYKYDVDKEMT 205
Query: 1771 LLKFVDDQWGPVGSFNWFATHGTSMSRTNELISGDNKGTAARLMEDWFDQKTAGRIVNVN 1592
L+KFVD Q GP GSFNWFATHGTSMSRTN LISGDNKG AAR MEDWF+ + + N
Sbjct: 206 LVKFVDSQLGPTGSFNWFATHGTSMSRTNSLISGDNKGAAARFMEDWFENGQKNSVSSRN 265
Query: 1591 -PRRVSNIVQGPQGNHHELLELAASFKSTSGKPVTKYXXXXXXXXXXXXXXDRPRFVSAF 1415
PRRVS IV N LL++AA++KS+ G V K + +FVSAF
Sbjct: 266 IPRRVSTIVSDFSRNRDRLLDIAATYKSSRGHSVDK----SLDVKTRVRNGSKRKFVSAF 321
Query: 1414 CQSNCGDVSPNILGAFCTDTGLPCDFNHSTCGGKNELCYGRGPGYPDEFESTRIIGERQF 1235
CQSNCGDVSPN LG FC DTGLPCDFNHSTC G+NELCYGRGPGYPDEFESTRIIGE+QF
Sbjct: 322 CQSNCGDVSPNTLGTFCIDTGLPCDFNHSTCNGQNELCYGRGPGYPDEFESTRIIGEKQF 381
Query: 1234 KKAADLFNTASEKLNGKIDFRHSYLDFTQLEVTLPKQGGGSETVKTCXXXXXXXXXXXXX 1055
K A +LFN A+EKL GKI ++H+YLDF+ L+VT+PK GGGSETVKTC
Sbjct: 382 KMAVELFNKATEKLQGKIGYQHAYLDFSNLDVTVPKAGGGSETVKTCPAAMGFGFAAGTT 441
Query: 1054 XXXXXXXFKQGDNTGNPFWKLVRNVLKTPSKEQKDCQQPKPILLDTGEMKQPYDWAPSIL 875
FKQGD+ GN FW+LVRNVL+TP EQ CQ+PKPILLDTGEMK+PYDWAPSIL
Sbjct: 442 DGPGAFDFKQGDDQGNVFWRLVRNVLRTPGPEQVQCQKPKPILLDTGEMKEPYDWAPSIL 501
Query: 874 PVQMLKIGQMVILSVPGEFTTMAGRRLRDAVSAV--------FKEKVHVVIAGLTNTYSQ 719
P+Q+L+IGQ+VILSVPGEFTTMAGRRLRDA+ + F +HVVIAGLTNTYSQ
Sbjct: 502 PIQILRIGQLVILSVPGEFTTMAGRRLRDAIKSFLISSDPKEFSNNMHVVIAGLTNTYSQ 561
Query: 718 YITTYEEYEMQRYEGASTLYGPHTLSAYIQEFTKLATAIVTGKPVEAGPQPPDLLDKQIS 539
YI T+EEYE+QRYEGASTLYG HTL+AYIQEF KLATA+V G + GPQPPDLLDKQIS
Sbjct: 562 YIATFEEYEVQRYEGASTLYGRHTLTAYIQEFKKLATALVNGLTLPRGPQPPDLLDKQIS 621
Query: 538 LLPGVVVDSTPLGVKFGDVKTDIAKDSTFKKGDTVTVVFWSACPRNDLMTEGTFALVELL 359
LL VVVDSTPLGVKFGDVK D+ STF++G V FWS CPRNDLMTEG+FA+VE L
Sbjct: 622 LLSPVVVDSTPLGVKFGDVKADVPPKSTFRRGQQVNATFWSGCPRNDLMTEGSFAVVETL 681
Query: 358 QGQDTWVPAFDDDDICLRFKWSRPSKLSAQSHATIEWRIPQSTASGVYRVTHFGASKNLF 179
+ W P +DDDD L+FKWSRP+KLS++S ATIEWR+P+S +GVYR+ H+GASK+LF
Sbjct: 682 REGGKWAPVYDDDDFSLKFKWSRPAKLSSESQATIEWRVPESAVAGVYRIRHYGASKSLF 741
Query: 178 GSISHFTGSSSAFVV 134
GSIS F+GSSSAFVV
Sbjct: 742 GSISSFSGSSSAFVV 756
>sp|Q0JL46|NCASE_ORYSJ Neutral ceramidase OS=Oryza sativa subsp. japonica
GN=Os01g0624000 PE=1 SV=1
Length = 785
Score = 1067 bits (2757), Expect = 1e-310
Identities = 513/769 (66%), Positives = 607/769 (78%), Gaps = 24/769 (3%)
Frame = -2
Query: 2374 WFWVLLLVFAHNAEKAISASNYLVGLGSYDITGPAADVNMMGYANSDQTASGIHFRLRSR 2195
W W+LL + N +SAS YLVG+GS+DITGPAADVNMMGYAN++Q ASGIHFRL+SR
Sbjct: 20 WLWLLLALVLLNCSLVLSASPYLVGMGSFDITGPAADVNMMGYANTEQIASGIHFRLKSR 79
Query: 2194 AFIVAEPQGNRVVFVNLDACMGSQLVTLKVLERLKARYGNLYTEKNVAISGIHTHAGPGG 2015
AFIVAEP G RVVFVN+DACM SQ+VT+KVLERLKARYG+LY E NVAISGIHTHAGPGG
Sbjct: 80 AFIVAEPNGKRVVFVNIDACMASQIVTIKVLERLKARYGDLYNENNVAISGIHTHAGPGG 139
Query: 2014 YLQYVVYIVTSLGFVRQSFDALVDGIEQSIILAHDNLHSGSVYVNKGEILDAGVNRSPSA 1835
YLQYVVYIVTSLGFVRQSFD +VDGIEQSI+ AH+NL G ++VNKG++LDAGVNRSPSA
Sbjct: 140 YLQYVVYIVTSLGFVRQSFDVIVDGIEQSIVEAHNNLRPGKIFVNKGDLLDAGVNRSPSA 199
Query: 1834 YLNNPSAERAKYKYDVDKEMTLLKFVDDQWGPVGSFNWFATHGTSMSRTNELISGDNKGT 1655
YLNNP+ ER+KY+Y+VDKEMTL+KFVDD+ GPVGSFNWFATHGTSMSRTN LISGDNKG
Sbjct: 200 YLNNPAEERSKYEYNVDKEMTLIKFVDDELGPVGSFNWFATHGTSMSRTNSLISGDNKGA 259
Query: 1654 AARLMEDWFDQKTAGR--------------IVNVNPRRVSNIVQGPQGNHHELLELAASF 1517
AAR MEDW +Q + +V PRRVS I+ P +L++LA+S+
Sbjct: 260 AARFMEDWAEQMGLPKQSAHANSDDLRSLHKTSVLPRRVSTIIPEPNEITDDLIQLASSY 319
Query: 1516 KSTSGKPVTKYXXXXXXXXXXXXXXDRPRFVSAFCQSNCGDVSPNILGAFCTDTGLPCDF 1337
+++ G+ + ++P+FVSAFCQSNCGDVSPN+LG FC DT LPCDF
Sbjct: 320 EASGGR---RLAGSSITRRIRSTQQNKPKFVSAFCQSNCGDVSPNVLGTFCIDTNLPCDF 376
Query: 1336 NHSTCGGKNELCYGRGPGYPDEFESTRIIGERQFKKAADLFNTASEKLNGKIDFRHSYLD 1157
NHSTC GKNELCYGRGPGYPDEFESTR+IG RQF KA DLF++ASE++ GKID+RH+YLD
Sbjct: 377 NHSTCNGKNELCYGRGPGYPDEFESTRVIGNRQFLKARDLFDSASEEIQGKIDYRHTYLD 436
Query: 1156 FTQLEVTLPKQGGGSETVKTCXXXXXXXXXXXXXXXXXXXXFKQGDNTGNPFWKLVRNVL 977
F++LEV + GG +TVKTC F+QGD GNPFWKLVRN+L
Sbjct: 437 FSKLEVKVSTSAGGQQTVKTCPAAMGFAFAAGTTDGPGAFDFRQGDVKGNPFWKLVRNLL 496
Query: 976 KTPSKEQKDCQQPKPILLDTGEMKQPYDWAPSILPVQMLKIGQMVILSVPGEFTTMAGRR 797
KTP K+Q +C PKPILLDTGEMK+PYDWAP+ILPVQM++IGQ+VIL VPGEFTTMAGRR
Sbjct: 497 KTPGKDQVECHSPKPILLDTGEMKEPYDWAPAILPVQMIRIGQLVILCVPGEFTTMAGRR 556
Query: 796 LRDAVSAV-------FKEKVHVVIAGLTNTYSQYITTYEEYEMQRYEGASTLYGPHTLSA 638
LRDAV V F + +HVV+AGLTN+YSQYITT+EEY++QRYEGASTLYGPHTLSA
Sbjct: 557 LRDAVKTVLTSGNSEFDKNIHVVLAGLTNSYSQYITTFEEYQIQRYEGASTLYGPHTLSA 616
Query: 637 YIQEFTKLATAIVTGKPVEAGPQPPDLLDKQISLLPGVVVDSTPLGVKFGDVKTDIAKDS 458
YIQEF KLA A++ K V QPPD+LDKQI LLPGVV DSTPLGVKFGDV +D+ +S
Sbjct: 617 YIQEFQKLAMAMIANKEVPTNFQPPDMLDKQIGLLPGVVFDSTPLGVKFGDVNSDVPGNS 676
Query: 457 TFKKGDTVTVVFWSACPRNDLMTEGTFALVELLQGQDTWVPAFDDDDICLRFKWSRPSKL 278
TF KG TV F+SACPRNDL+T+GTFALVE L G + WVP +DDDD LRFKWSRP++L
Sbjct: 677 TFNKGSTVNATFYSACPRNDLLTDGTFALVEKLDGNNNWVPVYDDDDWSLRFKWSRPARL 736
Query: 277 SAQSHATIEWRIPQSTASGVYRVTHFGASKNLFGSISHFTGSSSAFVVK 131
S++S AT+EW +P+ A+GVYR+ HFGASK +FGS+ HFTG+S AF V+
Sbjct: 737 SSRSFATLEWTVPEDAAAGVYRLRHFGASKPMFGSVRHFTGTSRAFAVR 785
>sp|Q55G11|NCSEB_DICDI Neutral ceramidase B OS=Dictyostelium discoideum GN=dcd2B
PE=3 SV=1
Length = 718
Score = 374 bits (960), Expect = 3e-102
Identities = 204/440 (46%), Positives = 268/440 (60%), Gaps = 15/440 (3%)
Frame = -2
Query: 1429 FVSAFCQSNCGDVSPNILGAFCTDTGLPCDFNHSTCGGKNELCYGRGPGYP-DEFESTRI 1253
FV+AF QSN GDVSPN G C D G PCD+ STC G+NE C+ GPG D FEST+I
Sbjct: 285 FVAAFGQSNEGDVSPNTRGPTCRD-GSPCDYKTSTCNGRNEECWSLGPGKDGDMFESTQI 343
Query: 1252 IGERQFKKAADLFNTASEKLNGKIDFRHSYLDFTQLEVTLPKQGGGSETVKTCXXXXXXX 1073
IG QF KA +LFN AS +++G + +RHS++ FT + V P G + TC
Sbjct: 344 IGGNQFNKALELFNNASIQVSGPVQYRHSWVQFTNVSVE-PPYNSGVDNATTCRGAMGYS 402
Query: 1072 XXXXXXXXXXXXXFKQGDN--TGNPFWKLVRNVLKTPSKEQKDCQQPKPILLDTGEMKQP 899
F Q DN +GNPFW + + + P+ +Q CQ PKPILLD G M +P
Sbjct: 403 FAAGTTDGPGAFNFVQSDNNTSGNPFWNFIGDFIAKPTPDQIRCQSPKPILLDVG-MVEP 461
Query: 898 YDWAPSILPVQMLKIGQMVILSVPGEFTTMAGRRLRDAVSAVFKEKVH---VVIAGLTNT 728
W P ++P+Q++ IGQ+V+++VPGEFTTM+GRRLR++V + E + V+IAGL+NT
Sbjct: 462 IPWVPDVMPIQIVTIGQIVLVAVPGEFTTMSGRRLRNSVREIIGESIENPIVLIAGLSNT 521
Query: 727 YSQYITTYEEYEMQRYEGASTLYGPHTLSAYIQEFTKLATAIVTGKPVEAGPQPPDLLDK 548
YS YI T+EEY++QRYEGAST++GPHTL +Y+QEF KLA +IV G V AGP P +L
Sbjct: 522 YSGYIATFEEYQVQRYEGASTVFGPHTLGSYMQEFGKLAQSIVDGTTVPAGPTPRNLTGH 581
Query: 547 QISLLPGVVVDSTPLGVKFGDVKTDIAKDSTFKKGDTVTVVFWSACPRNDLMTEGTFALV 368
+ LP V+VD+ P FG+V D+ + + +TV+ VF+ PRND M E +F V
Sbjct: 582 TLFFLPPVIVDAAPDFDDFGEVSIDV--NLNYSVNETVSCVFYGGNPRNDFMIESSFLSV 639
Query: 367 ELLQGQDTWVPAFDDDDICLRFKWSRPSKLSAQSHATIEWRIPQSTASGVYRVTHFG-AS 191
+LL G D W DD D +FKW S TIEW I T G YR+TH G A
Sbjct: 640 DLLTGTDQWTTVLDDGDWDTKFKWKMHD--LGFSLITIEWVIAPDTTPGTYRITHSGFAK 697
Query: 190 KNLFGS-ISHFTGSSSAFVV 134
KN F S ++ + G S FVV
Sbjct: 698 KNPFSSNLTPYQGISRNFVV 717
Score = 232 bits (591), Expect = 2e-059
Identities = 113/233 (48%), Positives = 160/233 (68%), Gaps = 1/233 (0%)
Frame = -2
Query: 2332 KAISASNYLVGLGSYDITGPAADVNMMGYANSDQTASGIHFRLRSRAFIVAEPQGNRVVF 2153
K+ S+Y +G G YDITG +A+VN+MGYAN Q +GIHFR R+RAF+ + GNR V+
Sbjct: 39 KSSGDSSYQIGAGIYDITGASAEVNLMGYANPLQVGAGIHFRQRARAFVFVDSNGNRAVY 98
Query: 2152 VNLDACMGSQLVTLKVLERLKARYG-NLYTEKNVAISGIHTHAGPGGYLQYVVYIVTSLG 1976
V+ D+CM Q V + V+E L+ +G N+YTE NV +SG HTH+GP G+ QY +Y +TSLG
Sbjct: 99 VSTDSCMIFQEVKIHVVELLQDIFGPNVYTEANVLLSGTHTHSGPAGFSQYALYGITSLG 158
Query: 1975 FVRQSFDALVDGIEQSIILAHDNLHSGSVYVNKGEILDAGVNRSPSAYLNNPSAERAKYK 1796
F +++FD + +GI Q+I+ AH ++ +++ GE+ + +NRSP AY NNP E+A Y
Sbjct: 159 FYKKNFDTICNGIVQAIVKAHKSVQPANMFTETGELWNTNINRSPFAYDNNPEEEKAMYD 218
Query: 1795 YDVDKEMTLLKFVDDQWGPVGSFNWFATHGTSMSRTNELISGDNKGTAARLME 1637
+VDK MT+L+ D P + ++FA H TSM+ TN LISGDNKG A+ L E
Sbjct: 219 SNVDKNMTVLRIEDMNGNPFAAISFFAVHCTSMNNTNHLISGDNKGYASYLWE 271
>sp|Q54BK2|NCSEA_DICDI Neutral ceramidase A OS=Dictyostelium discoideum GN=dcd2A
PE=1 SV=1
Length = 714
Score = 350 bits (896), Expect = 7e-095
Identities = 191/440 (43%), Positives = 259/440 (58%), Gaps = 12/440 (2%)
Frame = -2
Query: 1429 FVSAFCQSNCGDVSPNILGAFCTDTGLPCDFNHSTCGGKNELCYGRGPGYP-DEFESTRI 1253
F++AF QSN GDVSPN G C D G PCD+ STC GK E C+ GPG D FEST+I
Sbjct: 280 FIAAFGQSNEGDVSPNTRGPTCRD-GKPCDYKTSTCNGKVEECWALGPGTDGDMFESTQI 338
Query: 1252 IGERQFKKAADLFNTASEKLNGKIDFRHSYLDFTQLEVTLPKQGGGSETVKTCXXXXXXX 1073
IG QF KA +LFN A+ +++GKI +RH++ FT + V P G E TC
Sbjct: 339 IGGNQFNKALELFNNATIQVSGKIQYRHTWKPFTNVSVEAP-YNSGVEGATTCRGAMGYS 397
Query: 1072 XXXXXXXXXXXXXFKQGDN-TGNPFWKLVRNVLKTPSKEQKDCQQPKPILLDTGEMKQPY 896
F QGDN T NPFW + ++ P+ +Q CQ PKPIL+D G M +P
Sbjct: 398 FAGGTTDGPGAFNFIQGDNSTTNPFWNFIGGIIAKPTPQQTACQAPKPILIDVG-MVEPI 456
Query: 895 DWAPSILPVQMLKIGQMVILSVPGEFTTMAGRRLRDAVSAVFKEKVH---VVIAGLTNTY 725
W P ++P+Q++ +GQ+V+++VPGEFTTM+GRRLR+ V + + + V+IAGL NTY
Sbjct: 457 PWVPDVMPLQIITLGQIVLVAVPGEFTTMSGRRLRNTVREIIGQSIENPIVLIAGLANTY 516
Query: 724 SQYITTYEEYEMQRYEGASTLYGPHTLSAYIQEFTKLATAIVTGKPVEAGPQPPDLLDKQ 545
S YI T+EE+++QRYEGAST++GPHTL AY QEF LA +IV G + G P ++
Sbjct: 517 SGYIATFEEFQVQRYEGASTVFGPHTLGAYQQEFANLAQSIVDGSQADPGTFPRNMSGHT 576
Query: 544 ISLLPGVVVDSTPLGVKFGDVKTDIAKDSTFKKGDTVTVVFWSACPRNDLMTEGTFALVE 365
LP V+VD P FGD+ TD++ + + TVTV+F+ A RN+ MTE +F V+
Sbjct: 577 PFFLPPVIVDVAPKFDDFGDIYTDVSTTTPYSINQTVTVIFYGANLRNNFMTESSFLTVD 636
Query: 364 LLQGQDTWVPAFDDDDICLRFKWSRPSKLSAQSHATIEWRIPQSTASGVYRVTHFG-ASK 188
LQ W +D D + W S T++W I T G YR+TH G A K
Sbjct: 637 QLQSNGQWTTILNDGDWDTKLYWKMHD--LGFSLITVDWTISPITQPGTYRITHSGYAKK 694
Query: 187 NLFG-SISHFTGSSSAFVVK 131
N F +++ + G SS F V+
Sbjct: 695 NPFSDNLTFYQGISSNFNVQ 714
Score = 225 bits (573), Expect = 2e-057
Identities = 109/236 (46%), Positives = 156/236 (66%), Gaps = 1/236 (0%)
Frame = -2
Query: 2341 NAEKAISASNYLVGLGSYDITGPAADVNMMGYANSDQTASGIHFRLRSRAFIVAEPQGNR 2162
N K S+Y +G G YDITGP A+ NMMGYA Q GIHFR R+RAF+ + +GNR
Sbjct: 30 NHIKLSDDSSYQIGTGIYDITGPGAETNMMGYAMPGQITGGIHFRQRARAFVFIDSEGNR 89
Query: 2161 VVFVNLDACMGSQLVTLKVLERLKARYG-NLYTEKNVAISGIHTHAGPGGYLQYVVYIVT 1985
V+V+ D+CM Q V ++V++ L+ +G LYT NV +SG HTH+GP G+ +Y +Y +T
Sbjct: 90 AVYVSTDSCMIFQEVKIQVIQDLQEIFGPTLYTHDNVLLSGTHTHSGPAGFSEYALYGIT 149
Query: 1984 SLGFVRQSFDALVDGIEQSIILAHDNLHSGSVYVNKGEILDAGVNRSPSAYLNNPSAERA 1805
+LGF +++FD + DGI Q+I+ AH ++ + +GE+ ++ +NRSP AY NNP E+A
Sbjct: 150 ALGFYKKNFDTICDGIVQAIVKAHKSVQPARMLTQQGELWNSNINRSPYAYDNNPEEEKA 209
Query: 1804 KYKYDVDKEMTLLKFVDDQWGPVGSFNWFATHGTSMSRTNELISGDNKGTAARLME 1637
Y +VDK MT+++ D P + ++F H TSM+ TN LISGDNKG A+ L E
Sbjct: 210 MYDANVDKNMTVIRIEDMSGNPFAAISFFGVHCTSMNNTNHLISGDNKGYASYLWE 265
>sp|Q29C43|NCASE_DROPS Neutral ceramidase OS=Drosophila pseudoobscura
pseudoobscura GN=CDase PE=3 SV=1
Length = 704
Score = 306 bits (783), Expect = 9e-082
Identities = 175/444 (39%), Positives = 234/444 (52%), Gaps = 13/444 (2%)
Frame = -2
Query: 1432 RFVSAFCQSNCGDVSPNILGAFCTDTGLPCDFNHSTCGGKNELCYGRGPGYPDEFESTRI 1253
+FV AFC SN GDVSPNI+G C+ +G CD S C C+ GPG D EST+I
Sbjct: 262 KFVGAFCSSNLGDVSPNIMGPKCSISGNECDLLTSRCPAGEGECFASGPG-RDMVESTQI 320
Query: 1252 IGERQFKKAADLFNTASE-----KLNGKIDFRHSYLDFTQLEVTLPKQ-GGGSETVKTCX 1091
+G+R A L N S+ ++ G + F H ++D + + ++ C
Sbjct: 321 LGQRLADAALGLLNEQSQESTAREVTGDVRFIHQFVDMPNYNGSAYNPLSRKIDKIRGCQ 380
Query: 1090 XXXXXXXXXXXXXXXXXXXFKQGDNTGNPFWKLVRNVLKTPSKEQKDCQQPKPILLDTGE 911
F+QG T NP W VR+ + TP++E C +PKPILL TG
Sbjct: 381 PAMGYSFAAGTTDGPGAFSFEQGTTTDNPMWNFVRDFIATPTQEDIKCHEPKPILLATGR 440
Query: 910 MKQPYDWAPSILPVQMLKIGQMVILSVPGEFTTMAGRRLRD----AVSAVFKEKVHVVIA 743
PY+W P I+ Q+LKIG ++I +VP EFTTMAGRRLR+ A SA V+IA
Sbjct: 441 ATFPYEWQPKIVSDQLLKIGDVIIAAVPCEFTTMAGRRLRNQIRAAASAAGGLDTEVIIA 500
Query: 742 GLTNTYSQYITTYEEYEMQRYEGASTLYGPHTLSAYIQEFTKLATAIVTGKPVEAGPQPP 563
GLTN Y+ Y T EEY+ QRYE AST++GPHT S Y+ F +L A++ + VE GP PP
Sbjct: 501 GLTNIYTSYTVTPEEYQAQRYEAASTIFGPHTHSIYMDVFERLTKALMRNETVEPGPSPP 560
Query: 562 DLLDKQISLLPGVVVDSTPLGVKFGDVKTDIAKDSTFKKGDTVTVVFWSACPRNDLMTEG 383
+ D +SL GV+ D P+ FG VKT K+ + DTV V + S PRN+L TE
Sbjct: 561 YMNDVMLSLNTGVLFDGHPINTDFGYVKTQPEKE--YGINDTVKVTYISGNPRNNLFTEK 618
Query: 382 TFALVELLQGQDTWVPAFDDDDICLRFKWSRPSKLSAQSHATIEWRIPQSTASGVYRVTH 203
T+ VE +D W A+ D + W R + + S I W I T GVYR+ H
Sbjct: 619 TYFTVERKINEDRWKVAYTDASWETKMIWHRTNTILGFSDLEIYWNISPQTLPGVYRIRH 678
Query: 202 FGASKNLFGSISHFTGSSSAFVVK 131
G K + G + G S +F VK
Sbjct: 679 SGEYKYILGGKYPYEGLSHSFTVK 702
Score = 239 bits (608), Expect = 2e-061
Identities = 122/275 (44%), Positives = 178/275 (64%), Gaps = 11/275 (4%)
Frame = -2
Query: 2326 ISASNYLVGLGSYDITGPAADVNMMGYANSDQTASGIHFRLRSRAFIVAEPQGNRVVFVN 2147
++++ Y VG+G DITGP ++N MGYAN Q GIH R+ +RAF+V + +GNRV FV+
Sbjct: 20 LASATYKVGVGRADITGPPVEINFMGYANIKQVGRGIHTRVFARAFVVEDEKGNRVAFVS 79
Query: 2146 LDACMGSQLVTLKVLERLKARYGNLYTEKNVAISGIHTHAGPGGYLQYVVYIVTSLGFVR 1967
DA M + +V++RL+ARYGNLY NVAISG HTH PGG+L +++Y ++ LGFV
Sbjct: 80 ADAGMMGYGLKREVIKRLQARYGNLYHTDNVAISGTHTHGAPGGFLMHLLYDISILGFVP 139
Query: 1966 QSFDALVDGIEQSIILAHDNLHSGSVYVNKGEILDAGVNRSPSAYLNNPSAERAKYKYDV 1787
Q+F+ + G+ I A DNL G ++++K +L+ +NRSP++YL NP ERA+Y++D
Sbjct: 140 QTFEVMAQGLYLCIKRATDNLVDGRIFLSKTTVLNVNINRSPTSYLRNPEEERAQYEHDT 199
Query: 1786 DKEMTLLKFVDDQWGPVGSFNWFATHGTSMSRTNELISGDNKGTAARLMEDWFDQ----- 1622
DK +T L+FVD + +G+FNW+A H TSM+ TN L++ DN G AA L+E ++
Sbjct: 200 DKTLTQLRFVDLENNLLGAFNWYAVHATSMNNTNRLVTSDNVGYAALLLEKEYNPNKMPG 259
Query: 1621 --KTAGRIVNVNPRRVSNIVQGPQ----GNHHELL 1535
K G + N VS + GP+ GN +LL
Sbjct: 260 KGKFVGAFCSSNLGDVSPNIMGPKCSISGNECDLL 294
>sp|Q9VA70|NCASE_DROME Neutral ceramidase OS=Drosophila melanogaster GN=CDase
PE=1 SV=1
Length = 704
Score = 243 bits (619), Expect = 9e-063
Identities = 135/365 (36%), Positives = 191/365 (52%), Gaps = 7/365 (1%)
Frame = -2
Query: 1210 TASEKLNGKIDFRHSYLDFTQLE-VTLPKQGGGSETVKTCXXXXXXXXXXXXXXXXXXXX 1034
+ + ++ G + F H ++D T + ++ C
Sbjct: 340 STAREVTGDVRFIHQFVDMPNYNGSTYNPLSRKVDKIRGCQPAMGYSFAAGTTDGPGAFS 399
Query: 1033 FKQGDNTGNPFWKLVRNVLKTPSKEQKDCQQPKPILLDTGEMKQPYDWAPSILPVQMLKI 854
F+QG T NP W VR+ + P++E C +PKPILL TG PY+W P I+ Q+LKI
Sbjct: 400 FEQGTTTDNPMWNFVRDFIAAPTQEDIKCHEPKPILLATGRATFPYEWQPKIVSDQLLKI 459
Query: 853 GQMVILSVPGEFTTMAGRRLRD----AVSAVFKEKVHVVIAGLTNTYSQYITTYEEYEMQ 686
G ++I +VP EFTTMAGRRLR+ A SAV V+IAGLTN Y+ Y T EEY+ Q
Sbjct: 460 GDVIIAAVPCEFTTMAGRRLRNQIRAAASAVGGIDTEVIIAGLTNIYTSYTVTPEEYQAQ 519
Query: 685 RYEGASTLYGPHTLSAYIQEFTKLATAIVTGKPVEAGPQPPDLLDKQISLLPGVVVDSTP 506
RYE AST++GPHT S Y+ F +L A++ + V+AGP PP + D +SL GV+ D P
Sbjct: 520 RYEAASTIFGPHTHSIYMDVFERLTKAMMRNETVDAGPSPPYMNDVMLSLNTGVLFDGHP 579
Query: 505 LGVKFGDVKTDIAKDSTFKKGDTVTVVFWSACPRNDLMTEGTFALVELLQGQDTWVPAFD 326
+ FG VK+ K+ + +TV V + S PRN+L TE T+ +E +D W A+
Sbjct: 580 INTDFGYVKSQPNKE--YGINETVKVTYISGNPRNNLFTEKTYFTIERKINEDRWKVAYT 637
Query: 325 DDDICLRFKWSRPSKLSAQSHATIEWRIPQSTASGVYRVTHFGASKNLFGSISHFTGSSS 146
D + W R + + S I W I T G YR+ H G K + G + G +
Sbjct: 638 DASWETKMVWHRTNTILGFSEMDIYWDISPQTLPGEYRIRHSGEYKYILGGKYPYEGLTH 697
Query: 145 AFVVK 131
+F VK
Sbjct: 698 SFTVK 702
Score = 237 bits (604), Expect = 5e-061
Identities = 122/273 (44%), Positives = 176/273 (64%), Gaps = 11/273 (4%)
Frame = -2
Query: 2320 ASNYLVGLGSYDITGPAADVNMMGYANSDQTASGIHFRLRSRAFIVAEPQGNRVVFVNLD 2141
++ Y VG+G DITGP ++N MGYAN Q GIH R+ +RAF+V + +GNRV FV+ D
Sbjct: 22 SATYKVGVGRADITGPPVEINFMGYANIKQVGRGIHTRVFARAFVVEDEKGNRVAFVSAD 81
Query: 2140 ACMGSQLVTLKVLERLKARYGNLYTEKNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQS 1961
A M + +V++RL+ARYGN+Y NVAISG HTH PGG+L +++Y ++ LGFV Q+
Sbjct: 82 AGMMGYGLKREVIKRLQARYGNIYHNDNVAISGTHTHGAPGGFLMHLLYDISILGFVPQT 141
Query: 1960 FDALVDGIEQSIILAHDNLHSGSVYVNKGEILDAGVNRSPSAYLNNPSAERAKYKYDVDK 1781
F+ + G+ I A DNL G + ++K +L+ +NRSPS+YL NP+ ERA+Y++D DK
Sbjct: 142 FEVMAQGLYLCIKRATDNLVDGRILLSKTTVLNVNINRSPSSYLRNPAEERAQYEHDTDK 201
Query: 1780 EMTLLKFVDDQWGPVGSFNWFATHGTSMSRTNELISGDNKGTAARLMEDWFDQ------- 1622
+T L+FVD + +G+FNW+A H TSM+ TN L++ DN G AA L+E ++
Sbjct: 202 TLTQLRFVDLENNLLGAFNWYAVHATSMNNTNRLVTSDNVGYAALLLEKEYNPNKMPGKG 261
Query: 1621 KTAGRIVNVNPRRVSNIVQGPQ----GNHHELL 1535
K G + N VS + GP+ GN +LL
Sbjct: 262 KFVGAFCSSNLGDVSPNIMGPKCSISGNECDLL 294
>sp|Q5W7F1|ASAH2_DANRE Neutral ceramidase OS=Danio rerio GN=asah2 PE=1 SV=1
Length = 743
Score = 236 bits (601), Expect = 1e-060
Identities = 111/225 (49%), Positives = 157/225 (69%), Gaps = 1/225 (0%)
Frame = -2
Query: 2311 YLVGLGSYDITGPAADVNMMGYANSDQTASGIHFRLRSRAFIVAEPQGNRVVFVNLDACM 2132
YL+G+G D TGP AD+ MMGYAN+DQTA G+H RL SRAFIV + RVVFV D M
Sbjct: 61 YLIGVGRADCTGPVADLPMMGYANTDQTARGLHTRLFSRAFIV-DDGNKRVVFVTSDIGM 119
Query: 2131 GSQLVTLKVLERLKARYGNLYTEKNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQSFDA 1952
SQ + L+V + LK +YG+LY + NV +SG HTH+G GGY QY ++++TS G+++ S A
Sbjct: 120 VSQRLRLEVFQALKEKYGDLYRQDNVVLSGTHTHSGVGGYFQYTLFMITSKGYIKPSIQA 179
Query: 1951 LVDGIEQSIILAHDNLHSGSVYVNKGEILDAGVNRSPSAYLNNPSAERAKYKYDVDKEMT 1772
+V GI +SI +AH NL G +++NKG++ D+ NRSP +Y+NNP ER +Y+++ DK++
Sbjct: 180 IVSGIVKSIDIAHRNLRPGRIFINKGQVADSNFNRSPHSYMNNPEEERNRYEFNTDKQIV 239
Query: 1771 LLKFVDDQWGPVGSFNWFATHGTSMSRTNELISGDNKGTAARLME 1637
+LKF D +G +WFA H SM+ TN ++S DN G A+ + E
Sbjct: 240 VLKFTDLDGDGIGLLSWFAVHPVSMNYTNRMVSSDNLGYASYIFE 284
>sp|Q9NR71|ASAH2_HUMAN Neutral ceramidase OS=Homo sapiens GN=ASAH2 PE=1 SV=2
Length = 780
Score = 231 bits (589), Expect = 3e-059
Identities = 116/244 (47%), Positives = 159/244 (65%), Gaps = 4/244 (1%)
Frame = -2
Query: 2317 SNYLVGLGSYDITGPAADVNMMGYANSDQTASGIHFRLRSRAFIVAEPQG-NRVVFVNLD 2141
S Y +G+G D TG AD+N+MGY S Q A GI RL SRAFI+AEP G NR VFV++D
Sbjct: 100 SGYHIGVGRADCTGQVADINLMGYGKSGQNAQGILTRLYSRAFIMAEPDGSNRTVFVSID 159
Query: 2140 ACMGSQLVTLKVLERLKARYGNLYTEKNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQS 1961
M SQ + L+VL RL+++YG+LY NV +SG HTH+GP GY QY V+++ S GF Q+
Sbjct: 160 IGMVSQRLRLEVLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQT 219
Query: 1960 FDALVDGIEQSIILAHDNLHSGSVYVNKGEILDAGVNRSPSAYLNNPSAERAKYKYDVDK 1781
F +V GI +SI +AH N+ G +++NKG + +NRSP +YL NP +ERA+Y + DK
Sbjct: 220 FQHMVTGILKSIDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDK 279
Query: 1780 EMTLLKFVDDQWGPVGSFNWFATHGTSMSRTNELISGDNKGTAARLMEDWFDQKTAGRIV 1601
EM +LK VD +G +WFA H SM+ +N L++ DN G A+ L+E +K G +
Sbjct: 280 EMIVLKMVDLNGDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLE---QEKNKGYLP 336
Query: 1600 NVNP 1589
P
Sbjct: 337 GQGP 340
>sp|Q91XT9|ASAH2_RAT Neutral ceramidase OS=Rattus norvegicus GN=Asah2 PE=1 SV=1
Length = 761
Score = 231 bits (588), Expect = 4e-059
Identities = 114/244 (46%), Positives = 160/244 (65%), Gaps = 4/244 (1%)
Frame = -2
Query: 2317 SNYLVGLGSYDITGPAADVNMMGYANSDQTASGIHFRLRSRAFIVAEPQG-NRVVFVNLD 2141
S Y +G+G D TG +D+N+MGY + Q A G+ RL SRAFI+A+P G NR+ FV+++
Sbjct: 81 SGYYIGVGRADCTGQVSDINLMGYGKNGQNAQGLLTRLFSRAFILADPDGSNRMAFVSVE 140
Query: 2140 ACMGSQLVTLKVLERLKARYGNLYTEKNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQS 1961
CM SQ + L+VL+RL+++YG+LY NV +S HTH+GP G+ QY +YI+ S GF ++
Sbjct: 141 LCMISQRLRLEVLKRLQSKYGSLYRRDNVILSATHTHSGPAGFFQYTLYILASEGFSNRT 200
Query: 1960 FDALVDGIEQSIILAHDNLHSGSVYVNKGEILDAGVNRSPSAYLNNPSAERAKYKYDVDK 1781
F +V GI +SI +AH NL G V +NKG + + +NRSPS+YL NP +ERA+Y D DK
Sbjct: 201 FQYIVSGIVKSIDIAHTNLKPGKVLINKGNVANVQINRSPSSYLQNPPSERARYSSDTDK 260
Query: 1780 EMTLLKFVDDQWGPVGSFNWFATHGTSMSRTNELISGDNKGTAARLMEDWFDQKTAGRIV 1601
EM +LK VD +G +WFA H SM+ +N L++ DN G AA L E +K G +
Sbjct: 261 EMVVLKLVDLNGEDLGLISWFAVHPVSMNNSNHLVNSDNMGYAAYLFE---QEKNRGYLP 317
Query: 1600 NVNP 1589
P
Sbjct: 318 GQGP 321
>sp|Q9JHE3|ASAH2_MOUSE Neutral ceramidase OS=Mus musculus GN=Asah2 PE=1 SV=1
Length = 756
Score = 229 bits (582), Expect = 2e-058
Identities = 112/244 (45%), Positives = 161/244 (65%), Gaps = 4/244 (1%)
Frame = -2
Query: 2317 SNYLVGLGSYDITGPAADVNMMGYANSDQTASGIHFRLRSRAFIVAEPQG-NRVVFVNLD 2141
S Y +G+G D TG +D+N+MGY + Q A G+ RL SRAFI+A+P G NR+ FV+++
Sbjct: 76 SGYYIGVGRADCTGQVSDINLMGYGKNGQNARGLLTRLFSRAFILADPDGSNRMAFVSVE 135
Query: 2140 ACMGSQLVTLKVLERLKARYGNLYTEKNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQS 1961
CM SQ + L+VL+RL+++YG+LY NV +S IHTH+GP G+ QY +YI+ S GF ++
Sbjct: 136 LCMISQRLRLEVLKRLESKYGSLYRRDNVILSAIHTHSGPAGFFQYTLYILASEGFSNRT 195
Query: 1960 FDALVDGIEQSIILAHDNLHSGSVYVNKGEILDAGVNRSPSAYLNNPSAERAKYKYDVDK 1781
F +V GI +SI +AH NL G +++NKG + + +NRSPS+YL NP +ERA+Y + DK
Sbjct: 196 FQYIVSGIMKSIDIAHTNLKPGKIFINKGNVANVQINRSPSSYLLNPQSERARYSSNTDK 255
Query: 1780 EMTLLKFVDDQWGPVGSFNWFATHGTSMSRTNELISGDNKGTAARLMEDWFDQKTAGRIV 1601
EM +LK VD +G +WFA H SM+ +N ++ DN G AA L E +K G +
Sbjct: 256 EMLVLKLVDLNGEDLGLISWFAIHPVSMNNSNHFVNSDNMGYAAYLFE---QEKNKGYLP 312
Query: 1600 NVNP 1589
P
Sbjct: 313 GQGP 316
>sp|Q9I596|NCASE_PSEAE Neutral ceramidase OS=Pseudomonas aeruginosa (strain ATCC
15692 / PAO1 / 1C / PRS 101 / LMG 12228) GN=PA0845 PE=1 SV=1
Length = 670
Score = 191 bits (484), Expect = 4e-047
Identities = 101/222 (45%), Positives = 141/222 (63%), Gaps = 3/222 (1%)
Frame = -2
Query: 2311 YLVGLGSYDITGPAADVNMMGYANSDQTASGIHFRLRSRAFIVAE-PQGNRVVFVNLDAC 2135
Y GLG DITG AA+V MMGY++ +Q +GIH R +RAF++ E G R+V+VN D
Sbjct: 29 YRFGLGKADITGEAAEVGMMGYSSLEQKTAGIHMRQWARAFVIEEAASGRRLVYVNTDLG 88
Query: 2134 MGSQLVTLKVLERLKARYGNLYTEKNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQSFD 1955
M Q V LKVL RLKA+Y +Y E NV ++ HTH+GPGG+ Y +Y ++ LGF ++F+
Sbjct: 89 MIFQAVHLKVLARLKAKYPGVYDENNVMLAATHTHSGPGGFSHYAMYNLSVLGFQEKTFN 148
Query: 1954 ALVDGIEQSIILAHDNLHSGSVYVNKGEILDAGVNRSPSAYLNNPSAERAKYKYDVDKEM 1775
A+VDGI +SI A L G ++ GE+ +A NRS ++L NP + Y+ +D +M
Sbjct: 149 AIVDGIVRSIERAQARLQPGRLFYGSGELRNANRNRSLLSHLKNP--DIVGYEDGIDPQM 206
Query: 1774 TLLKFVDDQWGPVGSFNWFATHGTSMSRTNELISGDNKGTAA 1649
++L FVD G+ +WF H TSM+ N LIS DNKG A+
Sbjct: 207 SVLSFVDANGELAGAISWFPVHSTSMTNANHLISPDNKGYAS 248
>sp|P0C7U2|ASA2C_HUMAN Putative neutral ceramidase C OS=Homo sapiens GN=ASAH2C
PE=2 SV=1
Length = 622
Score = 163 bits (412), Expect = 9e-039
Identities = 77/173 (44%), Positives = 111/173 (64%), Gaps = 3/173 (1%)
Frame = -2
Query: 2107 VLERLKARYGNLYTEKNVAISGIHTHAGPGGYLQYVVYIVTSLGFVRQSFDALVDGIEQS 1928
VL RL+++YG+LY NV +SG HTH+GP GY QY V+++ S GF Q+F +V GI +S
Sbjct: 13 VLNRLQSKYGSLYRRDNVILSGTHTHSGPAGYFQYTVFVIASEGFSNQTFQHMVTGILKS 72
Query: 1927 IILAHDNLHSGSVYVNKGEILDAGVNRSPSAYLNNPSAERAKYKYDVDKEMTLLKFVDDQ 1748
I +AH N+ G +++NKG + +NRSP +YL NP +ERA+Y + DKEM +LK VD
Sbjct: 73 IDIAHTNMKPGKIFINKGNVDGVQINRSPYSYLQNPQSERARYSSNTDKEMIVLKMVDLN 132
Query: 1747 WGPVGSFNWFATHGTSMSRTNELISGDNKGTAARLMEDWFDQKTAGRIVNVNP 1589
+G +WFA H SM+ +N L++ DN G A+ L+E +K G + P
Sbjct: 133 GDDLGLISWFAIHPVSMNNSNHLVNSDNVGYASYLLE---QEKNKGYLPGQGP 182
Database: Uniprot/SwissProt
Posted date: Thu Sep 27 17:53:50 2012
Number of letters in database: 190,795,139
Number of sequences in database: 537,505
Lambda K H
0.267 0.041 0.140
Gapped
Lambda K H
0.267 0.041 0.140
Matrix: blosum62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 153,672,307,831
Number of Sequences: 537505
Number of Extensions: 153672307831
Number of Successful Extensions: 912197726
Number of sequences better than 0.0: 0
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